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Statins and death due to any cause - all doubts removed?

Title

Statins and death due to any cause – all doubts removed?

Authors

Ilija Barukčić  

Keywords

Statins | Causal relationship

Publication Details

Volume: 5; Issue: 12; Dec-2019 | ISSN: 2454-5422

Abstract

Objective:

To date, it is quite common to claim that some patient groups benefit from statin therapy in both primary and secondary prevention of cardiovascular disease while equally the use of higher-intensity statin therapies is emphasized. In this Review, the efficacy of statin therapy in light of the study data available is explored. 

Methods:

All in all, 40 studies with a sample size of n = 88388 were re-analyzed. The exclusion relationship was used to test the null-hypothesis: a certain statin does exclude death due to any cause. The causal relationship k was used to test the data for causality. The level of significance was set to Alpha = 0,05.

Results:

The data of the studies reanalyzed provide convincing evidence that statins unfortunately do not exclude death due to any cause. Overwhelming evidence suggests that the risk of harmful effects of statin therapy far outweigh any real or perceived benefit. 

Conclusions:

An immediate statin therapy discontinuation should be considered.

Citation:

Ilija Barukčić  “Statins and death due to any cause – all doubts removed ?”. International Journal of Current Science Research (IJCSR) 5.12(2019):  1884-1911.