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Synthesis and evaluation of substituted oxazolyl/Thiazolyl Thiazolidines and Azetidines derivatives for central nervous system depressant activity

Title

Synthesis and evaluation of substituted oxazolyl/Thiazolyl Thiazolidines and Azetidines derivatives for central nervous system depressant activity

Authors

Bhupender Singh Rawat et al.,

Keywords

Thiazolidine | Azetidine

Publication Details

Vol: 2; Iss: 8; Aug 16 | ISSN: 2454-5422

Abstract

Heterocyclic derivatives has been found in a large number of compounds which shows antibacterial, antifungal, anti-inflammatory, anti-tuberculosis, anticonvulsant activity. There is a close relation between the biological activity of the compounds on their molecular structures .The compounds containing thiazole, thiadiazole, oxazole, oxadiazole, imidazole, pyrimidine, pyridine and benzothiazoles rings have been found to exhibit broad spectrum of biological activities. In the present work, Oxazolyl/Thiazolyl-2`-(4-phenyl-3-Chloro-2-oxo-Azetidine) and Oxazolyl/Thiazolyl-2`-(5-phenyl-2-oxo-Thiazolidine) were synthesized. The different heterocyclic moieties were condensed with aromatic aldehyde in ethanol containing trace amount of glacial acetic acid which were converted into various azetidines and thiazolidines by reaction with thioglycolic acid and chloro acetyl chloride. The structures of the synthesized compounds were characterized on the basis of IR and HNMR spectral data. Among all synthesized selected compounds were screened for their CNS activity. Chlorpromazine hydrochloride is employed as a reference standard. From the results it is concluded that, synthesized compounds show more depressant activity than reference standard.

Citation:

Bhupender Singh Rawat, Shrawan Kumar Shukla, Nidhi Gangwar and Roopali Tandon. “Synthesis and evaluation of substituted oxazolyl/Thiazolyl Thiazolidines and Azetidines derivatives for central nervous system depressant activity”. International Journal of Current Science Research (IJCSR) 2.8 (2016):  856-874.