Protective Effect of d-Limonene against Adriamycin Induced Cardiac Injury in Rats – A Preliminary and Biochemical Study

Indumathi Selvanathan et al.,

Adriamycin | cardiotoxicity

Vol: 2; Iss: 7; Jul 16 | ISSN: 2454-5422

Adriamycin (ADR) is the conventional anthracycline antineoplastic drugs, treated against various solid tumors and malignancies. Its adverse effect was formation of oxidative stress and reactive oxygen species leads to cardiotoxicity due to cumulative dose of Adriamycin in chemotherapy. D-Limonene is an oil nutrient, occurs naturally in lemon and orange peels and it have various pharmaceutical properties like anti-oxidant, anti-inflammatory and anti-cancer etc. In this present study cardio protective effect of D-Limonene on cardiac marker enzymes, anti- oxidant enzymes was investigated in Adriamycin induced rats. Animals induced with Adriamycin with 2.5 mg/kg/body weight ip) leads to myocardial damage that was manifested by the increase in the level of cardiac marker enzymes like (LDH, CPK, GOT, GPT) enzymes and significant reduction in the level of anti-oxidant enzymes like (SOD, CAT, GPX, GST). Administration of D-limonene (100mg/kg/body weight) orally for two weeks prior before a period of injection of Adriamycin shows significant reduction in marker enzymes to normal range and increases in anti-oxidant activity. This result indicates, pre-co-treatment with Dlimonene have effectively protect against Adriamycin induced cardiotoxicity. Hence this present study was framed to detect cardioprotective role of d-limonene (d-Limo) against Adriamycin induced cardiac damage in albino male rats.