Synthesis, characterization and Antifungal activity of transition metal (II) complexes of Schiff base derived from p-aminoacetanilide and salicylaldehyde

Sakthivel et al.,                

Anti-fungal activity | Schiff base

Vol: 3; Iss: 5;  May-17 | ISSN: 2454-5422

Tridentate Schiff base (L) has been synthesized by condensation of salicylaldehyde and p- aminoacetanilide in ethanol and treating with copper, nickel, cobalt and zinc chlorides form metal complexes. The synthesized compounds are characterized by analytical and spectral methods. The results indicate that the complexes are having ML2 the composition. Moreover, geometry of the complexes is confirmed from electronic absorption and magnetic susceptibility data. The data show that all the complexes are distorted octahedral geometry around the central metal ion. The synthesized complexes were also exposed to various fungi to establish their bioactivities which show significant results. All the synthesized compounds are active against fungi but metal complexes are more active than ligand. Minimum Inhibitory Concentrations (MIC) values of synthesized compound range 25-55 mg/ml against fungal species.