Maha Hussein Abdoulrahman, et al.,

Pregnancy | Miscarriage | Intrauterine fetal death

Vol: 5; Iss: 1; Jan 19 | ISSN: 2454-5422

Pregnancy is a prothrombotic state, which is developed as a result of multifactorial reasons.
Physiological changes that induce relative hypercoagulable state and physical changes leading
to increased stasis. We aimed to assess possible thrombophilic parameters in women with a
history of adverse pregnancy outcome. This cross-sectional study included 90 pregnant
women during the second trimester of pregnancy divided into two groups. The Case group
(n=45) had a history of intrauterine growth restriction (IUGR), intrauterine foetal death
(IUFD), preterm labour or miscarriage. The Control group (n=45) included women with no
history of adverse pregnancy outcome. The level of prothrombin time (PT), activated partial
thromboplastin time (aPTT), fibrinogen (FBG), protein C (PC), protein S (PS), Antithrombin
III (AT III), Lupus anticoagulant (LA), Anticardiolipin (IgM and IgG), Haemoglobin (Hb)
and platelet (Plts) counts were measured. Patients with a history of bad pregnancy outcome
were shown to have significantly higher levels of FBG, LA and anticardiolipin antibodies
(IgM and IgG) and significantly lower levels of PS, PC and AT III compared to those with
normal pregnancy outcome. There was no significant difference in PT and aPTT levels
between the two groups. Patients with a history of adverse pregnancy outcome are at
increased risk of hypercoagulable state.