The Hepato-protective effect of Phyllanthus longiflorus Heyne Ex. Hook. F. in isoniazid and rifampicin induced hepatotoxicity in wistar rats

Manju | Muthulakshmi

Hepatoprotective activity |  Phyllanthus longiflorus

Vol: 2; Iss: 5; May 16 | ISSN: 2454-5422

 The present study was planned to evaluate the effect of ethanolic extract of Phyllanthus longiflorus against isoniazid and rifampicin induced hepatotoxicity in wistar rats. In this study, we observed the hepatoprotective effect of Phyllanthus longiflorus (EEPL) in Rifampicin (RIF) and Isoniazid (INH) induced hepatotoxicity in rats. A significant elevation was observed in the levels of serum AST, ALT, ALP and significant decrease level total protein and total albumin in G2 which received Rifampicin (RIF) and Isoniazid (INH) as compared to G1 rats who received normal saline. Elevated levels of these parameters in serum are presumptive markers of hepatotoxic lesions in the liver. On morphological examination in G4, 200mg/kg of Phyllanthus longiflorus (EEPL) showed partial recovery in some liver. In this study Flavonoids in Phyllanthus longiflorus (EEPL) might have a role in the recovery in Rifampicin (RIF) and Isoniazid (INH) induced hepatotoxicity in rats. The hepatoprotective role of Phyllanthus longiflorus (EEPL) might be due to its antioxidant potential mechanism suggesting that the extract of plant may be useful to prevent the oxidative stress induced damage. More research is required in this View-point to develop a good hepatoprotective drug from Phyllanthus longiflorus (EEPL) Purification of extracts and identification of the active principle may yield active Hepatoprotective ingredients.