Antitumor activity of ethanolic extract of Phyllanthus longiflorus Heyne Ex. Hook. F. against dalton’s ascitic lymphoma in mice

Manju | Muthulakshmi

Antitumor activity | Phyllanthus longiflorus    

Vol: 2; Iss: 4; Apr 16 | ISSN: 2454-5422

The present study was planned to evaluate the effect of Ethanolic extract of Phyllanthus longiflorus against Dalton’s Ascitic Lymphoma (DAL). Male Swiss albino mice (20-25gm) were procured from central animal house, and used throughout the study. Various technique for induction of cancer in animals, viz. chemically induced (using DMBA/croton oil. etc) virus induced, cell line induced (sarcoma–180, ULCA fibro sarcoma and Jensen sarcoma, mouse lung fibroblast cells L-929, Dalton’s Lymphoma Ascites (DLA), Ehrlich Ascites Carcinoma (EAC) methods have been used in experimental studies of anticancer activity. The antitumor nature of Phyllanthus longiflorus was evidenced by the significant reduction in percent increase in body weight of animal treated with               Phyllanthus longiflorus at the dose of 200 mg/kg and 400mg/kg body weight when compared to DLA tumor bearing mice. Treatment with Phyllanthus longiflorus at the dose of 200 mg/kg and 400mg/kg significantly increases the Hb content, RBC, Platelets and significantly decreased the WBC count to about normal level. The inoculation of DLA cells caused significantly increase in the level of Total Cholesterol, Aspartate amino Transferase, Alanine, amino Transferase, Alkaline Phosphatase in the tumor control animals(G2), when compared to the normal group.